Here are some friends with simlar question as we.And I have this question for many days,anyone help us?
Kitty said: Yes.Have anyone of you ever tried cocaine? (note: I'm not interested in trying it, j-I try seach this on internet but no results found.Maybe this is a stupid question.
Mike said: oh,no,you are wrong.I have found as below for this question(Have anyone of you ever tried cocaine? (note: I'm not interested in trying it, j),it will help you,my kids.
Lol don't think I'm stupid enough to try it, Im just curious.
Answer:
Oh yeah it's GREAT! It's so much fun, so unusual from your usual mind set. I love the stuff, but I won't touch it ever again. It's addictive in the sense that when it starts to wear off, you want more to boost you back up again. Depending on the stuff, one line can work from 10 minutes to 45 minutes, then when that wears off you do another one to keep it going. I won't touch it again though because the after affects are not worth it at ALL. Like when the last little bit wears off and there's no more to be sniffed, that's when it starts to suck real bad. Depending on the stuff you got, your nose and throat may hurt beyond reason, you've got a stuffy nose, and all you want to do is go to sleep because it's 6 in the morning but you CAN'T. As much as you WANT to go to sleep, it can't be done, no matter what. You just get in a blah mood, don't want to be around anybody but don't want to be alone either. It's hard to explain, but it isn't worth the fun of being on it. Not at all. I'd say try it once just to know what it's like. It's not addictive for life unless it's always available to you. If it comes around once or twice a year, you're safe.
yep
i tried it a few times in college. I wont lie... it's pretty awesome, but its soooooooooooooooo addictive. DO NOT TRY IT
Anesthetized.
Nope, never have and never will. Cocaine is for losers.
i sold coke , crack and pills. if you ever do try it you will try it again it like lays no one can toot just once
no way. wouldn't even know where to get it from. btw never tried any other drug either.
Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. It is a stimulant of the central nervous system and an appetite suppressant, creating what has been described as a euphoric sense of happiness and increased energy. Though most often used recreationally for this effect, cocaine is also a topical anesthetic used in eye, throat, and nose surgery. Cocaine is highly addictive and has the most reinforcing effect of any drug known.[1] Its possession, cultivation, and distribution is illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. The name comes from the name of the coca plant plus the alkaloid suffix -ine.
The stimulating qualities of the coca leaf were known to the ancient peoples of Peru and other Pre-Columbian South American societies. In modern Western countries, cocaine has been a feature of the counterculture for well-over a century; there is a long-list of prominent intellectuals, artists, and musicians who have used the drug — names ranging from Sir Arthur Conan Doyle and Sigmund Freud to United States President Ulysses S. Grant. For several decades after its initial release, cocaine could be found in trace amounts in the Coca-Cola beverage.[2] Today, although illegal in virtually all countries, cocaine remains popular in a wide variety of social and personal settings.
Mechanism of action
The pharmacodynamics of cocaine are complex. One significant effect of cocaine on the central nervous system is the blockage of the dopamine transporter protein (DAT), hence cocaine is called a dopamine reuptake inhibitor. Brain regions that are rich with dopaminergic neurons are the ventral tegmental area (VTA), and the substantia nigra (SN). The dopamine (DA) neurons of the VTA send axons to the nucleus accumbens (nAC)and the prefrontal cortex (PFC) and release DA presynaptically on the neurons in these regions. While the precise role of DA in the subjective experience of reward is controversial among neuroscientists, the release of DA in the nAC is widely considered to be responsible for cocaine's rewarding effects. This conclusion is largely based on laboratory data involving rats that are trained to self-administer cocaine intravenously (i.v.). If DA antagonists are infused directly into the nAC, well-trained rats self-administering cocaine will undergo extinction (i.e., initially increase responding only to stop completely) thereby indicating that cocaine is no longer reinforcing (i.e., rewarding) drug-seeking behavior.
A monoamine transmitter by a neuron for signal firing is normally recycled via the transporter to terminate the signal and to spare transmitter resources. The transporter binds the transmitter and pumps it out of the synaptic cleft back into the pre-synaptic neuron. There it is taken up into storage vesicles. Cocaine binds tightly at the DAT forming a complex that blocks the transporter's function, this also blocks the reuptake of the transmitter. Once released into the extracellular space (synaptic cleft) dopamine accumulates there, because the recycling mechanism is inhibited by the cocaine. This results in an enhanced and prolonged post-synaptic effect of dopaminergic signalling at dopamine receptors on the receiving neuron. Prolonged exposure to cocaine, as occurs with habitual use, leads to homeostatic dysregulation of normal (i.e., without cocaine) dopaminergic signaling via downregulation of D1 receptors and enhanced signal transduction. The decreased dopaminergic signalling after chronic cocaine use may contribute to depressive mood disorders and sensitize this important brain reward circuit to the reinforcing effects of cocaine (e.g., enhanced dopaminergic signalling only when cocaine is self-administered). This sensitization contributes to the intractable nature of addiction and relapse.
Cocaine is also a less potent blocker of the norepinephrine transporter (NET) and serotonin transporter (SERT). Cocaine also blocks sodium channels, thereby interfering with the propagation of action potentials; thus, like lignocaine and novocaine, it acts as a local anesthetic. Cocaine also causes vasoconstriction, thus reducing bleeding during minor surgical procedures. The locomotor enhancing properties of cocaine may be attributable to its enhancement of dopaminergic transmission from the substantia nigra. Recent research points to an important role of circadian mechanisms[18] and clock genes[19] in behavioral actions of cocaine.
Because nicotine increases the levels of dopamine in the brain, many cocaine users find that consumption of tobacco products during cocaine use enhances the euphoria. This, however, may have undesirable consequences, such as uncontrollable chain smoking during cocaine use (even users who don't normally smoke cigarettes have been known to chain smoke when using cocaine), in addition to the detrimental health effects and the additional strain on the cardiovascular system caused by tobacco.
if you need more open
I've never tried it but have had friends that have died or ruined their lives from it. Most people I've talked to about it say it makes them feel like Superman , like they can accomplish anything , and the other main effect is that they crave more and sometimes will stop at nothing to get it. Unless you want to end up on the streets , in jail or dead , I wouldn't try it and steer clear of people using it or are trying to get you to try it.I've had good friends steal from me to support their habit.
"Precious'" answer is the correct one.
hell ya love it ,but you have to have alot of self control or it will get yo in trouble.........it makes your brain really really happy
I agree with Precious, its fun while you have it and for some odd reason you forgot about the down side til the next day when you are praying to die. Every have a horrendous sinus headache---multiple that by 10 add to that the worse hangover of yr life.
...
Read this: All the information of cooking and health post by website user,chineseop.com not guarantee
correctness,It's Non-profit and only for informational purposes.
Kitty said: Yes.Have anyone of you ever tried cocaine? (note: I'm not interested in trying it, j-I try seach this on internet but no results found.Maybe this is a stupid question.
Mike said: oh,no,you are wrong.I have found as below for this question(Have anyone of you ever tried cocaine? (note: I'm not interested in trying it, j),it will help you,my kids.
Lol don't think I'm stupid enough to try it, Im just curious.
Answer:
Oh yeah it's GREAT! It's so much fun, so unusual from your usual mind set. I love the stuff, but I won't touch it ever again. It's addictive in the sense that when it starts to wear off, you want more to boost you back up again. Depending on the stuff, one line can work from 10 minutes to 45 minutes, then when that wears off you do another one to keep it going. I won't touch it again though because the after affects are not worth it at ALL. Like when the last little bit wears off and there's no more to be sniffed, that's when it starts to suck real bad. Depending on the stuff you got, your nose and throat may hurt beyond reason, you've got a stuffy nose, and all you want to do is go to sleep because it's 6 in the morning but you CAN'T. As much as you WANT to go to sleep, it can't be done, no matter what. You just get in a blah mood, don't want to be around anybody but don't want to be alone either. It's hard to explain, but it isn't worth the fun of being on it. Not at all. I'd say try it once just to know what it's like. It's not addictive for life unless it's always available to you. If it comes around once or twice a year, you're safe.
yep
i tried it a few times in college. I wont lie... it's pretty awesome, but its soooooooooooooooo addictive. DO NOT TRY IT
Anesthetized.
Nope, never have and never will. Cocaine is for losers.
i sold coke , crack and pills. if you ever do try it you will try it again it like lays no one can toot just once
no way. wouldn't even know where to get it from. btw never tried any other drug either.
Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. It is a stimulant of the central nervous system and an appetite suppressant, creating what has been described as a euphoric sense of happiness and increased energy. Though most often used recreationally for this effect, cocaine is also a topical anesthetic used in eye, throat, and nose surgery. Cocaine is highly addictive and has the most reinforcing effect of any drug known.[1] Its possession, cultivation, and distribution is illegal for non-medicinal and non-government sanctioned purposes in virtually all parts of the world. The name comes from the name of the coca plant plus the alkaloid suffix -ine.
The stimulating qualities of the coca leaf were known to the ancient peoples of Peru and other Pre-Columbian South American societies. In modern Western countries, cocaine has been a feature of the counterculture for well-over a century; there is a long-list of prominent intellectuals, artists, and musicians who have used the drug — names ranging from Sir Arthur Conan Doyle and Sigmund Freud to United States President Ulysses S. Grant. For several decades after its initial release, cocaine could be found in trace amounts in the Coca-Cola beverage.[2] Today, although illegal in virtually all countries, cocaine remains popular in a wide variety of social and personal settings.
Mechanism of action
The pharmacodynamics of cocaine are complex. One significant effect of cocaine on the central nervous system is the blockage of the dopamine transporter protein (DAT), hence cocaine is called a dopamine reuptake inhibitor. Brain regions that are rich with dopaminergic neurons are the ventral tegmental area (VTA), and the substantia nigra (SN). The dopamine (DA) neurons of the VTA send axons to the nucleus accumbens (nAC)and the prefrontal cortex (PFC) and release DA presynaptically on the neurons in these regions. While the precise role of DA in the subjective experience of reward is controversial among neuroscientists, the release of DA in the nAC is widely considered to be responsible for cocaine's rewarding effects. This conclusion is largely based on laboratory data involving rats that are trained to self-administer cocaine intravenously (i.v.). If DA antagonists are infused directly into the nAC, well-trained rats self-administering cocaine will undergo extinction (i.e., initially increase responding only to stop completely) thereby indicating that cocaine is no longer reinforcing (i.e., rewarding) drug-seeking behavior.
A monoamine transmitter by a neuron for signal firing is normally recycled via the transporter to terminate the signal and to spare transmitter resources. The transporter binds the transmitter and pumps it out of the synaptic cleft back into the pre-synaptic neuron. There it is taken up into storage vesicles. Cocaine binds tightly at the DAT forming a complex that blocks the transporter's function, this also blocks the reuptake of the transmitter. Once released into the extracellular space (synaptic cleft) dopamine accumulates there, because the recycling mechanism is inhibited by the cocaine. This results in an enhanced and prolonged post-synaptic effect of dopaminergic signalling at dopamine receptors on the receiving neuron. Prolonged exposure to cocaine, as occurs with habitual use, leads to homeostatic dysregulation of normal (i.e., without cocaine) dopaminergic signaling via downregulation of D1 receptors and enhanced signal transduction. The decreased dopaminergic signalling after chronic cocaine use may contribute to depressive mood disorders and sensitize this important brain reward circuit to the reinforcing effects of cocaine (e.g., enhanced dopaminergic signalling only when cocaine is self-administered). This sensitization contributes to the intractable nature of addiction and relapse.
Cocaine is also a less potent blocker of the norepinephrine transporter (NET) and serotonin transporter (SERT). Cocaine also blocks sodium channels, thereby interfering with the propagation of action potentials; thus, like lignocaine and novocaine, it acts as a local anesthetic. Cocaine also causes vasoconstriction, thus reducing bleeding during minor surgical procedures. The locomotor enhancing properties of cocaine may be attributable to its enhancement of dopaminergic transmission from the substantia nigra. Recent research points to an important role of circadian mechanisms[18] and clock genes[19] in behavioral actions of cocaine.
Because nicotine increases the levels of dopamine in the brain, many cocaine users find that consumption of tobacco products during cocaine use enhances the euphoria. This, however, may have undesirable consequences, such as uncontrollable chain smoking during cocaine use (even users who don't normally smoke cigarettes have been known to chain smoke when using cocaine), in addition to the detrimental health effects and the additional strain on the cardiovascular system caused by tobacco.
if you need more open
I've never tried it but have had friends that have died or ruined their lives from it. Most people I've talked to about it say it makes them feel like Superman , like they can accomplish anything , and the other main effect is that they crave more and sometimes will stop at nothing to get it. Unless you want to end up on the streets , in jail or dead , I wouldn't try it and steer clear of people using it or are trying to get you to try it.I've had good friends steal from me to support their habit.
"Precious'" answer is the correct one.
hell ya love it ,but you have to have alot of self control or it will get yo in trouble.........it makes your brain really really happy
I agree with Precious, its fun while you have it and for some odd reason you forgot about the down side til the next day when you are praying to die. Every have a horrendous sinus headache---multiple that by 10 add to that the worse hangover of yr life.
...
correctness,It's Non-profit and only for informational purposes.
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